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Until such information is available, it is prudent to apply rules for spacing measles vaccine and TST to varicella vaccine and LAIV. No information on the effect of varicella-containing vaccine or LAIV (live attenuated influenza vaccine) on a TST is available. MMR can be given the same day as a TST, but if MMR has been given and 1 or more days have elapsed, in most situations a wait of at least 4 weeks is recommended before giving a routine TST. MMR vaccine may decrease the response to a TST, potentially causing a false-negative response in someone who actually has an infection with tuberculosis. For most vaccines, there are no TST timing restrictions. All vaccines, including MMR, can be given on the same day as a TST, or any time after a TST is applied.
#Negative tb test skin#
TST and Vaccine Administrationįrom the CDC's 12th Edition of the "Pink Book" Epidemiology and Prevention of Vaccine-Preventable Diseases: Infants and children who need a tuberculin skin test (TST) can and should be immunized. Please click here to access the Class B Follow-up Worksheet, instructions for the worksheet and follow-up recommendations. Information regarding Tuberculosis Class B Follow-up Worksheets can be found on the IDPH Refugee Health web page. tuberculosis specific antigens and, unlike the TB skin tests, are not affected by prior BCG vaccination and are not expected to give a false-positive result in persons who have received prior BCG vaccination.
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TST reactions should be interpreted regardless of BCG vaccination history. A history of BCG vaccine is not a contraindication for tuberculin skin testing or treatment for LTBI in persons with positive TST results. TST reactivity caused by BCG vaccine generally wanes with the passage of time, but periodic skin testing may prolong (boost) reactivity in vaccinated persons. The question of the effect of BCG vaccine on TST results often causes confusion. Testing and Treatment for TB in BCG-Vaccinated Persons BCG is used in many countries with a high prevalence of TB to prevent childhood tuberculous meningitis and miliary disease. Many persons born outside of the United States have been BCG-vaccinated. The QuantiFERON®-TB Gold test (QFT-G), QuantiFERON®-TB Gold In-Tube test (GFT-GIT) and T-SPOT®.TB test are approved TB blood tests by the Food and Drug Administration.īCG, or Bacille Calmette-Guérin, is a vaccine for TB disease. If your health care provider or local health department offers TB blood tests, only one visit is required to draw blood for the test. Interferon-gamma release assays (IGRAs) are blood tests that measure how the immune system reacts to the bacteria that cause TB. A person given the tuberculin skin test must return within 48 to 72 hours to have a trained health care worker look for a reaction on the arm. The TB skin test (Mantoux tuberculin skin test) is performed by injecting a small amount of fluid (called tuberculin) into the skin in the lower part of the arm. tuberculosis infection should also include epidemiological and the patient’s medical history. This should include checking for signs and symptoms suggestive of TB disease, a chest x-ray, and, when indicated, examination of sputum or other clinical samples for the presence of M. tuberculosis infection.Ī diagnosis of Latent Tuberculosis Infection (LTBI) requires that TB disease be excluded by medical evaluation. For IGRA test results either an indeterminate or borderline test result (T-SPOT® only) indicates an uncertain likelihood of M. tuberculosis infection is likely a negative result suggests that infection is unlikely. IGRAS and TSTs should be used as an aid in diagnosing infection with M. There are two kinds of tests that can be used to help detect TB infection - the TB skin test (TST) and TB blood tests or Interferon-Gamma Release Assays (IGRAS) (i.e., QuantiFERON®-TB Gold test (QFT-G), QuantiFERON®-TB Gold In-Tube test (GFT-GIT) and T-SPOT®.TB test).